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慢性电刺激诱发大鼠癫痫模型中核磁共振检测信号异常的非对称性与特征性行为发作的关系

韩丹, 张先荣, 唐岳枫, 刘买利, 尹世金

武汉大学医学院生理学教研室.湖北,武汉 430071；中科院武汉物理与数学研究所波谱与原子分子物理国家重点实验室.湖北,武汉 430071

摘要

慢性强直电刺激大鼠右背海马(DHPC)或右中部颞叶新皮质(MTNC),每日一次(60Hz,2s,0.4--0.6mA),连续7--10d。刺激DHPC(57.4%,8/14只)或MTNC(71.42%,10/14只)均能引起电极对侧出现非对称性脑区核磁共振(T_(2)-WI)信号增强。组织学切片证实与扩大的侧脑室吻合,可能涉及脑实质结构的损伤。

关键词： 非对称性; T2加权核磁共振成像; 原发性湿狗样抖; 海马; 中部颞叶新皮质; 大鼠

Characteristic behavioral seizures and abnormal signal asymmetry of magnetic resonance imaging in an electrogenic rat model of chronic epilepsy

Han Dan, Zhang Xianrong, Tang Yuefeng, Liu Maili, Yin Shijin

Department of Physiology,Medical College,Wuhan University.Wuhan 430071,Hubei；China

Abstract

Chronic tetani (60 Hz, 2 s, 0.4-0.6 mA) were administered to the dorsal hippocampus (DHPC) or the medial temporal lobe neocortex (MTNC) of rats, to study the role of the entorhinal cortex (EC)-hippocampal loop in temporal lobe epileptogenesis. This was repeated once a day for 7 or 10 days. Magnification of hyper-intensity was induced by tetanization of the HPC or the MTNC, as detected by contralateral T_(2) weighted magnetic resonance imaging (T_(2)-WI). The effects were associated with an enlarged volume of the lateral ventricle (LV), which was verified histologically.

Key words: Asymmetry;T_(2)-weighted magnetic resonance imaging;Primary wet dog shakes;Hippocampus;Medial temporal neocortext;Rats

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引用本文：

韩丹, 张先荣, 唐岳枫, 刘买利, 尹世金. 慢性电刺激诱发大鼠癫痫模型中核磁共振检测信号异常的非对称性与特征性行为发作的关系[J]. 生理学报 2001; 53 (3): .

Han Dan, Zhang Xianrong, Tang Yuefeng, Liu Maili, Yin Shijin. Characteristic behavioral seizures and abnormal signal asymmetry of magnetic resonance imaging in an electrogenic rat model of chronic epilepsy. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).