过刊浏览

甲硫-脑啡肽对大鼠DRG分离神经元ATP-激活内向电流的抑制

夏保芦, 吴子桢, 李肖, 李琴, 李之望

武汉市职工医学院生理教研室.湖北,武汉 430016；华中科技大学同济医学院实验医学研究中心.湖北,武汉 430030

摘要

met-Enk对 I_(ATP)的抑制效应为非竞争性抑制作用,可能是由于阿片受体激活后,经相应的胞内信号转导途径使ATP受体磷酸化所致。

关键词： ATP-激活电流; 甲硫-脑啡肽; 大鼠; DRG神经元; 抑制作用; 全细胞膜片钳技术

Inhibition of ATP-activated currents by met-Enk in isolated DRG neurons of the rat

Xia Baolu, Wu Zizhen, Li Xiao, Li Qin, Li Zhiwang

Wuhan Professional Medical College.Wuhan 430016,Hubei；China

Abstract

It is suggested that the inhibition by met-Enk of I_(ATP) is caused by activation of opiate receptor, which eventually results in phosphorylation of ATP receptor, mediated by modulation of G protein coupling and intracellular signal transduction.

Key words: ATP-activated current;Met-enkephaline;Rat;DRG neuron;Inhibition;Whole-cell patch clamp technique

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

夏保芦, 吴子桢, 李肖, 李琴, 李之望. 甲硫-脑啡肽对大鼠DRG分离神经元ATP-激活内向电流的抑制[J]. 生理学报 2001; 53 (3): .

Xia Baolu, Wu Zizhen, Li Xiao, Li Qin, Li Zhiwang. Inhibition of ATP-activated currents by met-Enk in isolated DRG neurons of the rat. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).