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热应激抑制神经元凋亡与核因子kappa B活性之间的关系

郑淑秋, 苏兴文, 邱鹏新, 陈丽君, 万翔, 颜光美

中山医科大学药理教研室.广东,广州 510089

摘要

热应激的神经保护作用与减弱NF-kappa B活性无关,而NF-kappa B激活可能参与了热应激抑制神经元凋亡的作用。

关键词： 核因子kappa B; 热应激; 小脑颗粒神经元; 凋亡

Relationship between heat stress suppression of neuroapoptosis and activation of nuclear kappa B in primary cultured rat cerebellar granule cells

Zheng Shuqiu, Su Xingwen, Qiu Pengxin, Chen Lijun, Wan Xiang, Yan Guangmei

Department of Pharmacology,Sun Yat-Sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The results suggest that the neuroprotection of heat stress has no relation to the suppression of NF-kappa B activity, and activation of NF-kappa B may promote antiapoptotic action of heat stress.

Key words: Nuclear factor kappa B;Heat stress response;Cerebellar granule neurons;Apoptosis

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引用本文：

郑淑秋, 苏兴文, 邱鹏新, 陈丽君, 万翔, 颜光美. 热应激抑制神经元凋亡与核因子kappa B活性之间的关系[J]. 生理学报 2001; 53 (3): .

Zheng Shuqiu, Su Xingwen, Qiu Pengxin, Chen Lijun, Wan Xiang, Yan Guangmei. Relationship between heat stress suppression of neuroapoptosis and activation of nuclear kappa B in primary cultured rat cerebellar granule cells. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).