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胍丁胺抑制大鼠颈动脉窦压力感受器活动

秦晓梅, 范振中, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

Agm对颈动脉窦压力感受器活动有抑制作用,此作用由IR和#alpha#_(2)-AR介导,并与颈动脉窦压力感受器活动时Ca~(2+)内流减少有关。

关键词： 胍丁胺; 压力感受器活动; 窦神经传入放电; 咪唑啉受体; α_(2)肾上腺素受体

Agmatine inhibits the afferent activity of carotid baroreceptor in rats

Qin Xiaomei, Fan Zhenzhong, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

These results indicate that Agm exerts an inhibitory action on carotid baroreceptor and such an action may be attributed to the reduction in calcium influx in carotid baroreceptor, which is mediated by IR and #alpha#_(2)-AR.

Key words: Agmatine;Baroreceptor activity;Carotid sinus nerve discharge;Imidazoline receptor;#alpha_(2) adrenoceptor

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引用本文：

秦晓梅, 范振中, 何瑞荣. 胍丁胺抑制大鼠颈动脉窦压力感受器活动[J]. 生理学报 2001; 53 (2): .

Qin Xiaomei, Fan Zhenzhong, He Ruirong. Agmatine inhibits the afferent activity of carotid baroreceptor in rats. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).