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心梗后心肌重构过程中AT_(1A)、AT_(2)受体表达的变化

卢宁, 田德志, 周莉, 姚泰, 朱依纯

复旦大学基础医学院生理学教研室,国家医学神经生物学重点实验室.上海 200032

摘要

为探讨AT_(1)、AT_(2)受体在心肌重构演变过程中的作用,该实验应用免疫组化、电镜技术和图像分析方法,观察了大鼠心梗后心肌重构过程中非梗塞区AT_(1)、AT_(2)受体表达的动态变化。结果提示:心梗后非梗塞区心肌AT_(1A)、AT_(2)受体表达先后上调,可能参与介导心肌重构过程。

关键词： 心肌梗塞; AT_(1A)受体; AT_(2)受体; 免疫组化; 心肌重构

Changes in expression of angiotensin subtype AT_(1A) and AT_(2) receptors in rats during cardiac remodeling following myocardial infarction

Lu Ning, Tian Dezhi, ZHOU Li, Yao Tai, Zhu Yichun

Department of Physiology,Medical Center of Fudan University.Shanghai 200032

Abstract

Immunohistochemical and electron microscopic techniques and image analysis were employed to investigate the regulation of cardiac AT_(1A) and AT_(2) subtype receptors in rats during cardiac remodeling following myocardial infarction (MI). Positive immunostaining for AT_(1A) and AT_(2) receptors was observed in myocytes and vessels and AT_(1A) being more than AT_(2).

Key words: Myocardial infarction;ATIA receptor;AT~(1A) receptor;Cardiac remodeling;Immunohistoche mistiy

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引用本文：

卢宁, 田德志, 周莉, 姚泰, 朱依纯. 心梗后心肌重构过程中AT_(1A)、AT_(2)受体表达的变化[J]. 生理学报 2001; 53 (2): .

Lu Ning, Tian Dezhi, ZHOU Li, Yao Tai, Zhu Yichun. Changes in expression of angiotensin subtype AT_(1A) and AT_(2) receptors in rats during cardiac remodeling following myocardial infarction. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).