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海葵毒素对心肌钠通道开放模式、动作电位及心电图QT间期的影响

李慈珍, 王红卫, 刘建立, 刘凯, 杨智fang, 刘远谋

上海第二医科大学生理教研室.上海 200025

摘要

ATXⅡ使钠通道的开放频率增加,钠通道中“长时间开放模式”的开放时间常数增大,动作电位的持续时间APD_(50)和APD_(90)也分别增加了23%和27%。ATXⅡ使动物心电图QT间期延长18.6%,QTc(校正的QT间期)增大18.9%。

关键词： 钠通道; ATXⅡ; 动作电位; 心电图; 长QT综合征

Effect of ATXII on opening modes of myocyte sodium channel, action potential and QT intervals of ECG

Li Cizhen, Wang Hongwei, Liu Jianli, Liu Kai, Yang Zhifang, Liu Yuanmou

Department of Physiology,Shanghai Second Medical University.Shanghai 200025

Abstract

The results suggest that the dynamics or modes of Na channel play an important role in determining the action potential duration and the QT interval of ECG. The dynamical changes in Na channels induced by genetic mutation may be partially responsible for the long QT syndrome.

Key words: Sodium channel;ATXII;Action potential;ECG;long QT syndrome

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引用本文：

李慈珍, 王红卫, 刘建立, 刘凯, 杨智fang, 刘远谋. 海葵毒素对心肌钠通道开放模式、动作电位及心电图QT间期的影响[J]. 生理学报 2001; 53 (2): .

Li Cizhen, Wang Hongwei, Liu Jianli, Liu Kai, Yang Zhifang, Liu Yuanmou. Effect of ATXII on opening modes of myocyte sodium channel, action potential and QT intervals of ECG. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).