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P物质抑制培养大鼠海马大锥体细胞GABA-激活电流

熊顺华, 李之望, 樊友珍, 王明江, 魏劲波

郧阳医学院生理教研室.湖北,十堰 442000；同济医科大学实验医学研究中心.湖北,武汉 430030；湖北医科大学生理教研室.湖北,武汉 430071

摘要

SP对GABA激活电流的抑制作用是SP作用于SP受体,通过胞内第二信使,使GABA_(A)受体通道复合体胞内磷酸化所致。

关键词： 全细胞膜片箝技术; 海马大锥体细胞; P物质; GABA_(A)受体; 抑制作用

Substance P depresses GABA-activated currents in cultured hippocampal pyramidal neurons of rats

Xiong Shunhua, Li Zhiwang, Fan Youzhen, Wang Mingjiang, Wei Jingbo

Department of Physiology,Yunyang Medical College.Shiyan 442000,Hubei；China；Department of Physiology,Hubei Medical University.Wuhan 430071,Hubei

Abstract

Intracelllar application of H7, a potent inhibitor of PKC, abolished inhibition of I_(GABA) by SP, suggesting that the inhibition of I_(GABA) by SP may be a result of intracellular phosphorylation of the GABA_(A) receptor.

Key words: GABAA receptor;Substance P;Whole-cell-patch-clamp recording;Hyppcampl pyramidal neurons;Inhibition

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引用本文：

熊顺华, 李之望, 樊友珍, 王明江, 魏劲波. P物质抑制培养大鼠海马大锥体细胞GABA-激活电流[J]. 生理学报 2001; 53 (2): .

Xiong Shunhua, Li Zhiwang, Fan Youzhen, Wang Mingjiang, Wei Jingbo. Substance P depresses GABA-activated currents in cultured hippocampal pyramidal neurons of rats. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).