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整合素-配体结合反应上调兔支气管上皮细胞抗氧化能力

秦晓群, 向阳, 管茶香, 张长青, 孙秀泓

中南大学湘雅医学院生理学教研室.湖南,长沙 410078

摘要

用臭氧攻击培养的兔BEC,观察用Fn或其特异性识别域片段RGD肽处理后细胞内谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、过氧化氢酶(catalase)三种抗氧化酶活性变化和谷胱甘肽(GSH)含量的变化。结果提示,细胞外基质与整合素结合可增强细胞的抗氧化酶活性,增加GSH含量,以及提高抗氧化损伤能力。

关键词： 支气管上皮细胞; 整合素; 纤维连接蛋白; 抗氧化酶; 谷胱甘肽

Integrin-ligands binding reaction upregulates the antioxidant activity of rabbit bronchial epithelial cells

Qin Xiaoqun, Xiang Yang, Guan Chaxiang, Zhang Changqing, Sun Xiuhong

Department of Physiology,Xiangya Medical School,University of South-Central China.Changsha 410078,Hunan

Abstract

The data suggest that the binding of integrin with extracellular matrix can upregulate activity of antioxidant enzymes, and increase the content of GSH and improve the ability of BECs to resist oxidant injury.

Key words: bronchial epithelial cells;integrin;fibronectin;antioxidant enzymes;glutathione

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引用本文：

秦晓群, 向阳, 管茶香, 张长青, 孙秀泓. 整合素-配体结合反应上调兔支气管上皮细胞抗氧化能力[J]. 生理学报 2001; 53 (1): .

Qin Xiaoqun, Xiang Yang, Guan Chaxiang, Zhang Changqing, Sun Xiuhong. Integrin-ligands binding reaction upregulates the antioxidant activity of rabbit bronchial epithelial cells. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).