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内毒素引起的乳鼠心肌细胞血红素加氧酶-1基因的表达

李玉明, 刘俊昌, 张敏, 郑新程, 吴立玲, 时安云, 伍贻经

承德医学院低温生理研究室.河北,承德 067000；北京医科大学病理生理学教研室.北京 100083

摘要

LPS可诱导NRCMs HO-1 mRNA的表达,且在较低LPS剂量范围内具有时间依赖性和浓度依赖性;NRCMs HO-1 mRNA的表达可减低LPS引起的细胞损伤,这可能是细胞产生的一种自身保护性反应。

关键词： 内毒素; 血红素加氧酶; 基因表达

Expression of heme oxygenase-1 in neonatal rat cardiocytes induced by lipopolysaccharide

Li Yuming, Liu Junchang, Zhang Min, Zheng Xincheng, Wu Liling, Shi Anyun, Wu Yijing

Laboratory of Hypothermic Physiology,Chengde Medical College.Chengde 067000,Hebei；China

Abstract

The results demonstrate that LPS induces HO--1 mRNA expression of NRCMs dose- and time-dependently to some extent. The inducible HO can protect NRCMs from injury and thus play an important role in pathogenesis of myocardium under LPS.

Key words: gene expression; heme oxygenase ;

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引用本文：

李玉明, 刘俊昌, 张敏, 郑新程, 吴立玲, 时安云, 伍贻经. 内毒素引起的乳鼠心肌细胞血红素加氧酶-1基因的表达[J]. 生理学报 2001; 53 (1): .

Li Yuming, Liu Junchang, Zhang Min, Zheng Xincheng, Wu Liling, Shi Anyun, Wu Yijing. Expression of heme oxygenase-1 in neonatal rat cardiocytes induced by lipopolysaccharide. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).