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NO参与介导吗啡戒断大鼠脊髓神经元敏感化

曹君利, 曾因明, 张励才, 顾均, 周文华, 杨国栋

徐州医学院附属医院麻醉科.江苏,徐州 221002；江苏省麻醉学重点实验室.江苏,徐州 221002；宁波戒毒研究中心.浙江,宁波 315010

摘要

运用Fos免疫组织化学、NADPH-d组织化学、Fos/NADPH-d双标、鞘内注射和反义寡核苷酸技术,观察吗啡戒断大鼠脊髓神经元活动变化及NO在其中的作用。结果提示:NO参与介导吗啡戒断大鼠脊髓神经元敏感化。

关键词： 吗啡; 戒断; NO; 脊髓; 敏感化; Fos蛋白

NO involvement in mediation of spinal neuron sensitization in morphine-withdrawal rats

Cao Junli, Zeng Yinming, Zhang Licai, Gu Jun, Zhou Wenhua, Yang Guodong

Department of Anesthesiology,Affiliated Hospital of Xuzhou Medical College.Xuzhou 221002,Jiangsu；China；Ningbo Addiction Research and Treatment Center.Ningbo 315010,Zhejiang

Abstract

The effects of nitric oxide (NO) on the activation of spinal cord neurons were studied using immunocytochemistry, intrathecal injetion and antisense oligonucleotides (AS-ONs) techniques in morphine-withdrawal rats.

Key words: Morphine;withdrawal;NO;Spinal cord;sensitization;Fos protein

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引用本文：

曹君利, 曾因明, 张励才, 顾均, 周文华, 杨国栋. NO参与介导吗啡戒断大鼠脊髓神经元敏感化[J]. 生理学报 2001; 53 (1): .

Cao Junli, Zeng Yinming, Zhang Licai, Gu Jun, Zhou Wenhua, Yang Guodong. NO involvement in mediation of spinal neuron sensitization in morphine-withdrawal rats. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).