过刊浏览

MK-801降低炎性痛大鼠脊髓NOS表达和NO含量

曾静波, 李文斌, 李清君, 陈晓玲, 周爱民, 凌亦凌

河北医科大学基础医学研究所病理生理学研究室.河北,石家庄 050017

摘要

结果表明,皮下注射甲醛24h时,双侧脊髓后角NOS的表达及腰膨大部位NO的含量明显增加;而注射甲醛前15min及注射后12h两次鞘内注射NMDA受体拮抗剂MK-801,则明显抑制NOS的表达及NO含量的增加。

关键词： 炎性痛及痛过敏; 一氧化氮; 一氧化氮合酶; NMDA受体; MK-801; 脊髓

MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain

Zeng Jingbo, Li Wenbin, Li Qingjun, Chen Xiaoling, Zhou Aimin, Ling Yiling

Department of Pathophysiology,Basic Medical Institute,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results showed that the NOS expression and NO contents significantly increased 24 h after formalin injection, which were substantially inhibited when MK-801 was intrathecally injected 15 min prior to formalin injection or 12 h after formalin injection.

Key words: inflammatory pain and hyperalgesia;Nitric oxide;nitric oxide synthase;NMDA receptor;MK-801;Spinal cord

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

曾静波, 李文斌, 李清君, 陈晓玲, 周爱民, 凌亦凌. MK-801降低炎性痛大鼠脊髓NOS表达和NO含量[J]. 生理学报 2001; 53 (1): .

Zeng Jingbo, Li Wenbin, Li Qingjun, Chen Xiaoling, Zhou Aimin, Ling Yiling. MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).