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血管紧张素-(1-7)在大鼠延髓头端腹外侧通过氨基酸类递质调节血压的作用

王锦, 沈霖霖, 曹银祥, 孙钟杰, 王强, 朱大年

复旦大学医学院生理学教研室.上海 200032

摘要

采用微量注射、微透析、高效液相色谱-荧光测定等技术和方法,观察和分析了血管紧张素-(1-7)[Ang-(1-7)]在延髓头端腹外侧(RVLM)与氨基酸类递质释放之间的关系。结果提示,Ang-(1-7)在RVLM的升压效应可能部分是通过EAA释放增多所致;而Ang779在RVLM的降压效应可能部分是通过EAA释放减少、IAA释放增多所致。

关键词： 血管紧张素-(1-7); 延髓头端腹外侧; 血压; 氨基酸类递质

Role of angiotensin-(1-7) in amino-acid-neurotransmitter-mediated blood pressure regulation in rat rostral ventrolateral medulla

Wang Jin, Shen Linlin, Cao Yinxiang, Sun Zhongjie, Wang Qiang, Zhu Danian

Department of Physiology,Medical College,Fudan University.Shanghai 200032

Abstract

The present study was undertaken to investigate the linkage between angiotensin-(1-7) [Ang-(1-7)] and the release of amino acid neurotransmitters in the rostral ventrolateral medulla (RVLM) by techniques of microinjection, microdialysis combined with high performance liquid chromatography (HPLC)-fluorescent detection.

Key words: angiotensin-(1-7);rostral ventrolateral medulla;Blood pressure;amino acid neurotransmitt

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引用本文：

王锦, 沈霖霖, 曹银祥, 孙钟杰, 王强, 朱大年. 血管紧张素-(1-7)在大鼠延髓头端腹外侧通过氨基酸类递质调节血压的作用[J]. 生理学报 2001; 53 (1): .

Wang Jin, Shen Linlin, Cao Yinxiang, Sun Zhongjie, Wang Qiang, Zhu Danian. Role of angiotensin-(1-7) in amino-acid-neurotransmitter-mediated blood pressure regulation in rat rostral ventrolateral medulla. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).