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K_（ATP）通道开放剂对颈动脉窦压力感受器反射的易化作用

尹彤, 陈爽, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

以Cro（10 #mu# mol/L）隔离灌流大鼠左侧颈动脉窦区时，压力感受器机能曲线向左下方移位，曲线最大斜率（PS）由0.36±0.01增至0.48±0.01kPa/kPa (P<0.001)，反射性血压下降幅度（RD）由5.78±0.14增至7.87±0.12kPa (P<0.001)；阈压（TP）、平衡压（EP）和饱和压（SP）则分别从8.34±0.35，12.71±0.25和24.89±0.25下降至6.41±0.09kPa，11.78±0.24kPa，22.56±0.16kPa（P<0.01~0.001）。其中RD，PS和TP的变化呈明显的剂量依赖性。用K_（ATP）通道阻断剂格列苯脲（glibenclamide，10#mu# mol/L）预处理后，Cro的上述反射效应即被阻断。先给予腺苷（adenosine，125#mu# mol/L）则可以加强Cro对压力感受器反射的影响。

关键词： K_（ATP); 通道开放剂; 格列苯脲; 颈动脉窦压力感受器反射; 平均动脉压

K_(ATP) channel opener facilitates carotid sinus baroreflex in anesthetized rats

Yin Tong, Chen Shuang, He Ruirong

Department of Physiology, Institute of Basic Medicine, Hebei Medical University. Shijiazhuang 050017,Hebei

Abstract

The results obtained are as follows. (1) By perfusing the isolated carotid sinus with Cro (10#mu# mol/L),the functional curve of the baroreflex was shifted to the left and downward, with a peak slope (PS) in creasing from 0.36±0.01 to 0.48±0.01kPa/kPa (P<0.001), whereas the reflex decrease in mean arterial pressure (RD) was increased from 5.78±0.14 to 7.87±0.12kPa (P<0.001) . Meanwhile, the threshold pressure (TP), equilibrium pressure (EP) and saturation pressure (SP) were all singificantly decreased from 8.34±0.35 to 6.41±0.09kPa (P<0.01),12.71±0.25 to 11.78±0.24kPa (P<0.01) and 24.89±0.25 to 22.56±0.16kPa (P<0.001), respectively . Among the functional parameters of carotid baroreflex, the changes in RD,PS and TP induced by Cro were does-dependent. (2) By pretreatment with glibenclamide (10 #mu# mol/L),a K_(ATP) channel blocker, the above effect of Cro on the carotid baroreflex were abolished . (3) The Cro-induced change in the baroreflex was enhanced by preperfusing with adenosine (125 #mu# mol/L) . On the basis of the above result.

Key words: K_（ATP）;Channel opener;Glibenclamide;Carotid baroreflex mean;Arterial pressure

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引用本文：

尹彤, 陈爽, 何瑞荣. K_（ATP）通道开放剂对颈动脉窦压力感受器反射的易化作用[J]. 生理学报 2000; 52 (2): .

Yin Tong, Chen Shuang, He Ruirong. K_(ATP) channel opener facilitates carotid sinus baroreflex in anesthetized rats. Acta Physiol Sin 2000; 52 (2): (in Chinese with English abstract).