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降钙素基因相关肽对家兔离体窦房结电生理活动的影响

郭连峰, 钮伟真, 焦晓慧, 刘北英

首都医科大学心血管教研室.北京100054

摘要

低浓度CGRP（1nmol/L）对窦房结动作电位各参数无显著影响；中等浓度CGRP（10nmol/L）可增加最大舒张期电位、动作电位幅度、0期最大除极化速率和4期自动除极速率，缩短窦性周期、动作电位复极化50%和90%时间，这些作用经20min达到高峰；高浓度CGRP（100nmol/L）可引起窦房结节律失常。钙拮抗剂CdCl_（2）和verapamil可削弱由CGRP（20nmol/L）引起的窦房结细胞动作电位改变

关键词： 降钙素基因相关肽; 窦房结; 动作电位; 氯化镉; verapamil

Electrophysiological effects of calcitonin gene-related peptide on isolated sinoatrial node of the rabbit

Guo Lianfeng, Niu Weizhen, Jiao Xiaohui, Liu Beiying

Departments of Cardiovascular Physiology,Capital University of Medical Science.Beijing 100054

Abstract

It was found : (1) CGRP(1 nmol/L) had no effect on AP configuration ; CGRP (10 nmol/L) increased the maximal diastolic potential,AP amplitude and depolarization velocity of 0 and 4 phases, and decreased sinus cycle length and AP duration. After applying CGRP for 20 min the above effects reached to a maximum . CGRP(100 nmol/L) caused arrhythmia in the SAN . Calcium channel antagonists, CdCl_(2) and verapamil attenuated the electrophysiological changes in AP of SAN induced by CGRP (20 nmol/L).

Key words: CGRP;Sinoatrial node;Action potential;Cadmium chloride;Verapamil

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引用本文：

郭连峰, 钮伟真, 焦晓慧, 刘北英. 降钙素基因相关肽对家兔离体窦房结电生理活动的影响[J]. 生理学报 2000; 52 (2): .

Guo Lianfeng, Niu Weizhen, Jiao Xiaohui, Liu Beiying. Electrophysiological effects of calcitonin gene-related peptide on isolated sinoatrial node of the rabbit. Acta Physiol Sin 2000; 52 (2): (in Chinese with English abstract).