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尾加压素增加血管平滑肌细胞粘着斑激酶的含量和活力

彭旭, 尹航, 汪丽蕙, 柴三葆, 苏加林, 唐朝枢

北京医科大学第一医院心内科.北京 100034

摘要

在体外培养的血管平滑肌细胞上,采用蛋白印迹杂交免疫沉淀的方法,研究尾加压素Ⅱ(UⅡ)与粘着斑激酶(FAK)介导的信号传导之间的关系。UⅡ与FAK介导的信号转导途径之间存在着密切的关系,且这种关系不依赖于细胞骨架的完整性,与蛋白激酶C介导的信号转导途径有密切的关系。

Content and activity of the focal adhesion kinase in cultured vascular smooth muscle cells enhanced by urotensin II

Peng Xu, Yin Hang, Wang Lihui, Chai Sanbao, Su Jialin, Tang Chaoshu

Department of Cardiology,The First Hospital,Beijing Medical University.Beijing 100034

Abstract

Findings indicate that FAK activation is independent of the integrity of cytoskeleton and closely related to protein kinase C, but had no relation with mitogen activated protein kinase and calmodulin.

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引用本文：

彭旭, 尹航, 汪丽蕙, 柴三葆, 苏加林, 唐朝枢. 尾加压素增加血管平滑肌细胞粘着斑激酶的含量和活力[J]. 生理学报 2000; 52 (6): .

Peng Xu, Yin Hang, Wang Lihui, Chai Sanbao, Su Jialin, Tang Chaoshu. Content and activity of the focal adhesion kinase in cultured vascular smooth muscle cells enhanced by urotensin II. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).