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17#beta#-雌二醇对大鼠脑片穹隆下器神经元放电活动的调变作用

王红, 王志安, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

用细胞外记录技术,在大鼠脑片穹隆下器(subfornical organ,SFO)上观察了17#beta#-雌二醇(17#beta#-estradiol,E_(2))对SFO神经元放电的影响,并进而分析其作用机制。结果提示:E_(2)对SFO神经元有双重作用。小剂量E_(2)使SFO神经元放电增加,这一效应可能与谷氨酸受体激活有关;而大剂量E_(2)则导致神经元放电减少,此效应可归因于NOS激活而引发NO生成。

Modulatory effects of 17#beta#-estradiol on the electrical activity of subfornical organ neurons

Wang Hong, Wang Zhian, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The effects of 17#beta#-estradiol (E_(2)) on electrical activity of neurons in subfornical organ (SFO) slices were examined using extracellular recording technique.

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引用本文：

王红, 王志安, 何瑞荣. 17#beta#-雌二醇对大鼠脑片穹隆下器神经元放电活动的调变作用[J]. 生理学报 2000; 52 (6): .

Wang Hong, Wang Zhian, He Ruirong. Modulatory effects of 17#beta#-estradiol on the electrical activity of subfornical organ neurons. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).