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MKP-1在血管紧张素Ⅱ导致心肌肥大反应中的调控作用

刘培庆, 鲁伟, 王庭槐, 潘敬运

中山医科大学生理学教研室.广东,广州 510089

摘要

MAPK激活在AngⅡ导致的心肌肥大反应中具有重要作用,MKP-1通过使活化的MAPK去磷酸化而使MAPK失活,从而参与对心肌肥大反应的调节。

MKP-1 regulates the cardiomyocyte hypertrophic responses induced by angiotensin II

Liu Peiqing, Lu Wei, Wang Tinghuai, Pan Jingyun

Department of Physiology,Sun Yat-Sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The results demonstrate that activation of MAPK plays an important role in Ang II-induced cardiomyocyte hypertrophic response in neonatal rat cardiomyocytes through MKP-1 mediated inactivation of p44MAPK and p42MAPK.

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引用本文：

刘培庆, 鲁伟, 王庭槐, 潘敬运. MKP-1在血管紧张素Ⅱ导致心肌肥大反应中的调控作用[J]. 生理学报 2000; 52 (5): 365-370.

Liu Peiqing, Lu Wei, Wang Tinghuai, Pan Jingyun. MKP-1 regulates the cardiomyocyte hypertrophic responses induced by angiotensin II. Acta Physiol Sin 2000; 52 (5): 365-370 (in Chinese with English abstract).