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抗心律失常药RP62179对哺乳动物心室肌K~(+)电流的抑制

李玉荣, 杨宝峰, 徐长庆, 周晋, 杨永滨, 张季叶, 孙明智

哈尔滨医科大学生理教研室.黑龙江,哈尔滨 150086；哈尔滨医科大学药理教研室.黑龙江,哈尔滨 150086；哈尔滨医科大学病理生理教研室.黑龙江,哈尔滨 150086

摘要

使用全细胞膜片箝技术,研究RP62719对内向整流钾电流(I_(KI))、瞬时外向钾电流(I_(to))和延迟外向整流钾电流(I_(K))的作用,并探讨其抗心律失常作用的机制。

Inhibition of transmembrane K~(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719

Li Yurong, Yang Baofeng, Xu Changqing, Zhou Jin, Yang Yongbin, Zhang Jiye, Sun Mingzhi

Department of Physiology,Harbin Medical University.Harbin 150086,Heilongjiang；China；Department of Pathophysiology,Harbin Medical University.Harbin 150086,Heilongjiang

Abstract

The effect of RP62719 on the inward rectifier K~(+) current (I_(KI)), transient outward K~(+) current (I_(to)) and delayed outward K~(+) current (Ik) in isolated cardiac myocytes was determined using the whole cell patch clamp technique in guinea pig and dog.

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引用本文：

李玉荣, 杨宝峰, 徐长庆, 周晋, 杨永滨, 张季叶, 孙明智. 抗心律失常药RP62179对哺乳动物心室肌K~(+)电流的抑制[J]. 生理学报 2000; 52 (5): 427-430.

Li Yurong, Yang Baofeng, Xu Changqing, Zhou Jin, Yang Yongbin, Zhang Jiye, Sun Mingzhi. Inhibition of transmembrane K~(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719. Acta Physiol Sin 2000; 52 (5): 427-430 (in Chinese with English abstract).