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催产素对大鼠背根神经节分离细胞GABA激活电流的调制作用

谭振军, 魏劲波, 李之望, 邵梅, 胡祁生, 彭碧文

湖北医科大学生理教研室.湖北,武汉 430071；同济医科大学实验医学研究中心.湖北,武汉 430030

摘要

在急性分离的大鼠背根神经节(dorsal root ganglion,DRG)细胞上,应用全细胞膜片箝技术观察了预加催产素(oxytocin,OT)对GABA激活电流的调制作用。结果提示:OT受体激活后可能通过相应的胞内转导机制增强GABA激活电流,从而在初级感觉神经元水平加强GABA的突触前抑制作用而减弱感觉信息的传递。

Modulation of GABA-activated currents by oxytocin in rat dorsal root ganglion neurons

Tan Zhenjun, Wei Jingbo, Li Zhiwang, Shao Mei, Hu Qisheng, Peng Biwen

Department of Physiology,Hubei Medical University.Wuhan 430071,Hubei；China

Abstract

Experiments were performed on freshly isolated dorsal root ganglion (DRG) neurons of rat. GABA_(A)-activated currents were recorded using the whole-cell patch clamp technique. The majority of the neurons (48/52, 90.5%) were sensitive to GABA (10~(-6)-10~(-3) mol/L). The results suggest that the enhancement of GABA-activated currents by OT may suppress primary sensory transmission by potentiating pre-synaptic inhibition of GABA.

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引用本文：

谭振军, 魏劲波, 李之望, 邵梅, 胡祁生, 彭碧文. 催产素对大鼠背根神经节分离细胞GABA激活电流的调制作用[J]. 生理学报 2000; 52 (5): 381-384.

Tan Zhenjun, Wei Jingbo, Li Zhiwang, Shao Mei, Hu Qisheng, Peng Biwen. Modulation of GABA-activated currents by oxytocin in rat dorsal root ganglion neurons. Acta Physiol Sin 2000; 52 (5): 381-384 (in Chinese with English abstract).