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氯胺酮对单足致炎大鼠脊髓背角神经元活动的影响

郭华, 李菁锦, 吕国蔚

首都医科大学神经生物学系.北京 100054

摘要

在大鼠脊髓背角用细胞外记录技术共记录到32个单位。角叉菜胶一侧足底注射致炎后,电刺激该侧足底内外侧神经激动其中A、C纤维时,脊髓背角神经元的诱发放电数均显著增加;iv NMDA受体拮抗剂氯胺酮后,A、C纤维刺激诱发的放电反应均显著下降甚至消失。致炎后脊髓背角深层单位出现Windup现象,iv氯胺酮后该现象减轻或消失。

Effects of ketamine on neuronal activity of the spinal dorsal horn in rats with unilateral hindpaw inflammation

Guo Hua, Li Jingjin, Lu Guowei

Department of Neurobiology,Capital University of Medical Sciences.Beijing 100054

Abstract

A total of 32 units were extracellularly recorded from the spinal dorsal horn of rats. Unitary discharges evoked by stimulation of A and C fiber in ipsilateral lateral and medial plantar nerve were increased after carrageenan injection to be planter area. The evoked responses to both A and C fiber were significantly decreased or even disappeared after administration of ketamine. The windup phenomenon was observed in neurons located deeply in the dorsal horn following carrageenan injection and was significantly suppressed or abolished after ketamine administration.

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引用本文：

郭华, 李菁锦, 吕国蔚. 氯胺酮对单足致炎大鼠脊髓背角神经元活动的影响[J]. 生理学报 2000; 52 (4): .

Guo Hua, Li Jingjin, Lu Guowei. Effects of ketamine on neuronal activity of the spinal dorsal horn in rats with unilateral hindpaw inflammation. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).