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经脂多糖(LPS)处理免疫应答大鼠离体脑片视上核神经元对细胞因子敏感性的变化

王晓斌, 胡三觉, 鞠躬

第四军医大学神经科学研究所.陕西,西安 710032

摘要

实验采用离体脑片全细胞膜片箝记录方法,观察了细胞因子白介素-1#beta#(IL-1#beta#)和IL-2对大鼠离体脑片视上核神经元膜电位及自发放电的影响,以期探明免疫应答大鼠视上核神经元对细胞因子敏感性的变化。结果表明,在免疫应答中,视上核神经元对细胞因子IL-2的敏感性,在一定的程度上发生了改变,细胞因子IL-2可能参与了视上核神经元的功能调节,进而在免疫应答过程中发挥了调节作用。

Alteration of sensitivity of supraoptic nucleus neurons to cytokine in the hypothalamic slices from the rat after lipopolysaccharide injection

Wang Xiaobin, Hu Sanjue, Ju Gong

Institute of Neuroscience,the Fourth Military Medical University.Xi^an 710032,Shaanxi

Abstract

Using the whole-cell patch-clamp technique, the effects of interleukin-1#beta# (IL-1#beta#) and IL-2 on the membrane potential and spontaneous discharges in the supraoptic nucleus (SON) neurons from the rat hypothalamic slices in vitro were examined to determine the changes in sensitivity of supraoptic nucleus neurons to cytokine. The results show that the sensitivity of part of SON neurons from the immuned rat to cytokine IL-2 was altered, suggesting that IL-2 may be involved in modulation of the activity of SON neurons and thus play a role in modulation of the immune response.

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引用本文：

王晓斌, 胡三觉, 鞠躬. 经脂多糖(LPS)处理免疫应答大鼠离体脑片视上核神经元对细胞因子敏感性的变化[J]. 生理学报 2000; 52 (4): .

Wang Xiaobin, Hu Sanjue, Ju Gong. Alteration of sensitivity of supraoptic nucleus neurons to cytokine in the hypothalamic slices from the rat after lipopolysaccharide injection. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).