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TRPV4通道与脑缺血再灌注损伤的研究进展

丁浩, 林叶昕, 沈绮雯, 潘智, 王振超, 陈蕾

南京医科大学12012年级七年制临床医学系4班；生理学系，南京 210029

摘要

香草素受体4型瞬时感受器电位通道(transient receptor potential vanilloid 4 channel，TRPV4通道)是瞬时感受器电位通道家族成员之一。TRPV4通道是一种对钙离子具有选择通透性的阳离子通道，该通道激活后可以引起胞内钙离子浓度升高，进而参与调节机体多种生理或病理过程。现已证明，TRPV4通道可能在脑缺血再灌注所致的神经损伤中发挥重要作用。本文对近年来有关TRPV4通道与脑缺血再灌注损伤方面的研究进展予以综述。

关键词： TRPV4通道; 钙离子; 脑缺血再灌注

分类号：R743.3

[Research progress of TRPV4 and cerebral ischemic reperfusion injury.] [Article in Chinese]

DING Hao, LIN Ye-Xin, SHEN Qi-Wen, PAN Zhi, WANG Zhen-Chao, CHEN Lei

Class 4 Grade 2012, Seven-year Program of Clinical Medicine； Department of Physiology, Nanjing Medical University, Nanjing 210029, China

Abstract

Transient receptor potential vanilloid 4 (TRPV4) channel is a member of transient receptor potential superfamily. TRPV4 is selectively permeable to calcium. Activation of the TRPV4 channel induces an increase in intracellular calcium concentration and plays an important role under physiological and pathological conditions. Especially, there is evidence showing that TRPV4 is involved in cerebral ischemic reperfusion injury. The present paper reviewed some research progress about the role of TRPV4 in cerebral ischemic reperfusion injury.

Key words: transient receptor potential vanilloid 4 channel; calcium; cerebral ischemic reperfusion

收稿日期：2015-06-12　　录用日期：2015-07-29

通讯作者：陈蕾　　E-mail: chenl@njmu.edu.cn

引用本文：

丁浩, 林叶昕, 沈绮雯, 潘智, 王振超, 陈蕾. TRPV4通道与脑缺血再灌注损伤的研究进展[J]. 生理学报 2015; 67 (5): 527-532.

DING Hao, LIN Ye-Xin, SHEN Qi-Wen, PAN Zhi, WANG Zhen-Chao, CHEN Lei. [Research progress of TRPV4 and cerebral ischemic reperfusion injury.] [Article in Chinese]. Acta Physiol Sin 2015; 67 (5): 527-532 (in Chinese with English abstract).