过刊浏览

一氧化氮改变肾性高血压大鼠主动脉功能

郭益民, 朱小南, 潘敬运

温州医学院生理学教研室.浙江,温州 325027；中山医科大学生理学教研室.广东,广州 510089

摘要

探讨一氧化氮(NO)对二肾一夹(2K1C)肾性高血压大鼠主动脉功能的影响。实验分为5组:假手术、2K1C、卡托普利(captopril)、NAME(N_(#omega#)-Nitro-L-arginine methyl ester)和精氨酸组。结果提示:2K1C肾性高血压大鼠的主动脉内皮功能失调与NO生成和释放减少、肾素-血管紧张素系统活性增强有关,这些因素可能参与2K1C大鼠高血压的发生和维持。

Nitric oxide changes aortic function in rats with renal hypertension

Guo Yimin, Zhu Xiaonan, Pan Jingyun

Department of Physiology,Wenzhou Medical College.Wenzhou 325027,Zhejiang；China

Abstract

This work was undertaken to investigate the effect of nitric oxide (NO) on aortic function of two-kidney and one-clip (2K1C) rats with renal hypertension. Animals were divided into 5 groups: the sham operation, 2K1C, captopril, L-arginine and L-NAMe groups. Results suggest that deficiency of nitric oxide production and increase in renin-angiotensin system activity may contribute to vascular endothelial dysfunction of 2K1C rats, and these factors may be involved in development and maintenance of 2K1C renal hypertension.

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

郭益民, 朱小南, 潘敬运. 一氧化氮改变肾性高血压大鼠主动脉功能[J]. 生理学报 2000; 52 (3): .

Guo Yimin, Zhu Xiaonan, Pan Jingyun. Nitric oxide changes aortic function in rats with renal hypertension. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).