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缺血预处理减轻在体家兔心肌细胞凋亡

丁延峰, 张蔓蔓, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

在麻醉家兔心肌缺血-再灌注(ischemia-reperfusion,IR)模型上,观察IR和缺血预处理(ischemic preconditioning,IP)对血流动力学、心外膜电图、心肌梗塞范围、心肌细胞凋亡和凋亡相关调控基因蛋白(Fas、Bcl-2、Bax等)的影响。结果表明,IP减少IR引发的心肌细胞凋亡,并减少IR心肌组织中Fas蛋白的表达。

Ischemic preconditioning reduces cardiomyocytic apoptosis in rabbit heart in vivo

Ding Yanfeng, Zhang Manman, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The effects of ischemia-reperfusion (IR) and ischemic preconditioning (IP) on hemodynamics, epicardial electrography, myocardial infarct size, cardiomyocytic apoptosis and gene proteins involving apoptosis (Fas, Bcl-2 and Bax) were observed in aneasthetized rabbit myocardium. It is suggested that IP decreases cardiomyocytic apoptosis induced by IR and this action is mediated by the reduction of Fas protein expression.

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引用本文：

丁延峰, 张蔓蔓, 何瑞荣. 缺血预处理减轻在体家兔心肌细胞凋亡[J]. 生理学报 2000; 52 (3): .

Ding Yanfeng, Zhang Manman, He Ruirong. Ischemic preconditioning reduces cardiomyocytic apoptosis in rabbit heart in vivo. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).