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衰老性记忆障碍与脑突触体内游离[Ca~(2+)]_(i)的相关性

章子贵, 徐晓红, 杜红燕, 吴馥梅

浙江师范大学生物系生理教研室.浙江,金华 321004；南京大学生物科学与技术系神经生物学研究室.江苏,南京 210093

摘要

研究了12月龄和18月龄小鼠学习记忆能力的变化和18月龄小鼠四个脑区(海马、大脑皮层、四叠体和小脑)突触体内[Ca~(2+)]_(i)的水平,同时还比较了老年记忆保持良好组与记忆障碍组小鼠的脑钙水平。结果表明,随着年龄的增长,小鼠的学习记忆能力显著下降,上述脑区(除大脑皮层外)突触内[Ca~(2+)]_(i)均明显升高,其中老年记忆障碍小鼠脑钙水平升高最为显著。

关键词： 衰老性记忆障碍; 脑突触体; [Ca~（2+）]_(i); 小鼠

Correlation between the age-related memory impairment and the level of free Ca~(2+) in brain synaptosomes

Zhang Zigui, Xu Xiaohong, Du Hongyan, Wu Fumei

Department of Biology,Zhejiang Normal University.Jinhua 321004,Zhejiang；China

Abstract

In this study, we investigated the changes in the ability of learning-memory of 12-month- and 18-month-old mice, and the intrasynaptosomal Ca~(2+) levels of some mouse brain areas (hippocampus, cerebal cortex, corpus quadrigemi and cerebellum) on the basis of our last behavior observation and biochemistry detection. Meanwhile, the intrasynaptosomal Ca~(2+) levels of the four brain areas were compared between the mice of impaired and good memory. The main results are as follows. With the increase of age, the ability of learning-memory of mice decreased significantly; and the concentration of the intrasynaptosomal free [Ca~(2+)]_(i) in mouse brain areas (except for cerebral cortex) increased markedly, especially in the memory-impaired mice.

Key words: Age related memory impairment;Brain synaptosome;[Ca 2+ ]_(i);Mice

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引用本文：

章子贵, 徐晓红, 杜红燕, 吴馥梅. 衰老性记忆障碍与脑突触体内游离[Ca~(2+)]_(i)的相关性[J]. 生理学报 2000; 52 (1): .

Zhang Zigui, Xu Xiaohong, Du Hongyan, Wu Fumei. Correlation between the age-related memory impairment and the level of free Ca~(2+) in brain synaptosomes. Acta Physiol Sin 2000; 52 (1): (in Chinese with English abstract).