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电针和7-硝基吲唑对癫痫的效应及其与脑内一氧化氮的关系

黄志农, 杨茹, 陈刚, 程介士

上海医科大学神经生物学教研室,医学神经生物学国家重点实验室.上海 200032

摘要

神经源性NOS可增强癫痫的发作,但延长其诱导期。穴位针刺可能通过降低nNOS水平,减少NO的生成而抑制癫痫发作。

关键词： 癫痫; 一氧化氮; 电针; NO敏感电极; 7-硝基吲唑; 海马

Effect of electroacupuncture and 7-NI on penicillin-induced epilepsy and their relation with intrahippocampal NO changes

Huang Zhinong, Yang Ru, Chen Gang, Cheng Jieshi

National Laboratory of Medical Neurobiology,Department of Neurobiology,Shanghai Medical University.Shanghai 200032

Abstract

The propagation of penicillin-induced seizures is facilitated by nNOS, but with some increase in the latency and threshold of induction. Electroacupuncture may inhibit seizure through decreasing nNOS transcription in hippocampus.

Key words: Epilepsy;Nitric oxide(NO);Electroaupuncture;NO sensitive electrode;7-nitroindazole(7-NI);Hippocampus

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引用本文：

黄志农, 杨茹, 陈刚, 程介士. 电针和7-硝基吲唑对癫痫的效应及其与脑内一氧化氮的关系[J]. 生理学报 1999; 51 (5): .

Huang Zhinong, Yang Ru, Chen Gang, Cheng Jieshi. Effect of electroacupuncture and 7-NI on penicillin-induced epilepsy and their relation with intrahippocampal NO changes. Acta Physiol Sin 1999; 51 (5): (in Chinese with English abstract).