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内皮素-1前体基因反义寡核苷酸对正常和高血压大鼠血流动力学的影响

杜云鹏, 胡清华, 王建枝, 王迪浔

同济医科大学病理生理学教研室.湖北,武汉 430030

摘要

结果表明:针对内皮素-1(ET-1)前体基因反义硫代寡核苷酸片断(ETASODN)能抑制大鼠部分心血管中枢ET-1的生成,参与正常和腹主动脉狭窄-高盐摄入型高血压大鼠血压的中枢调节机制。

关键词： 高血压; 内皮素1; 反义寡核苷酸; 脑室注射

Effect of ET-1 antisense oligodeoxynucleotide on the hemodynamics of normal and experimental hypertensive rats

Du Yunpeng, Hu Qinghua, Wang Jianzhi, Wang Dixun

Department of Pathophysiology,Tongji Medical University.Wuhan 430030,Hubei

Abstract

It appears that (1) ET-1 might play an important role in central cardiovascular regulation in rats and (2) antisense ETASODN might be used in treatment of hypertension via inhibiting ET-1 production.

Key words: Hypertension;Endothelin-1;DNA antisense;Intracerebroventricular injection

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引用本文：

杜云鹏, 胡清华, 王建枝, 王迪浔. 内皮素-1前体基因反义寡核苷酸对正常和高血压大鼠血流动力学的影响[J]. 生理学报 1999; 51 (4): .

Du Yunpeng, Hu Qinghua, Wang Jianzhi, Wang Dixun. Effect of ET-1 antisense oligodeoxynucleotide on the hemodynamics of normal and experimental hypertensive rats. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).