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精氨酸加压素对大鼠抗体产生和淋巴细胞增殖的上调作用

白海波, 杜继曾, 郑筱祥

浙江大学生命科学与医学工程学系.浙江,杭州 310027；浙江大学生命科学与技术系.浙江,杭州 310027

摘要

大鼠侧脑室注射(icv)100ng精氨酸加压素(AVP),用ELISA法检测血中对鸡卵白蛋白抗原产生的IgG抗体水平。结果显示,IgG水平高于对照,而AVP的V_(1)受体阻断剂DPAVP(1-deamino-penicillamine 2-o-methyl-tyrosine-AVP)则可阻断此作用;icv 800ng AVP,大鼠的SRBC溶血素水平高于对照;icv 100ng、800ng AVP 2h后,脾淋巴细胞对MTT产生的颜色反应均比对照增加,而DPAVP可阻断之;icv 800ng AVP后,血清去甲肾上腺素(NE)水平明显低于对照,icv 100ng和800ng AVP,血清皮质酮水平下降。

关键词： 精氨酸加压素; IgG抗体; 淋巴细胞增殖; 免疫调节

The enhancing effects of arginine-vasopressin on antibody level and lymphocyte proliferation of rats

Bai Haibo, Du Jizeng, Zheng Xiaoxiang

Department of Biological Science and Medical Engineering,Zhejiang University.Hangzhou 310027,Zhejiang；China

Abstract

The effects of arginine-vasopressin (AVP) on some immune parameters of rats were studied by using icv of AVP. The hemolysin to sheep red blood cell and IgG production were enhanced by icv of 100, 800 ng AVP. Both the actions were partly blocked by icv preinjection of the V_(1) receptor antagonist DPAVP. It was also found that the NE and corticosterone levels in the serum of rats were significantly reduced after icv of AVP.

Key words: Arginine vasopressin;IgG antibody;Lymphocyte proliferation;Immunoregulation

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引用本文：

白海波, 杜继曾, 郑筱祥. 精氨酸加压素对大鼠抗体产生和淋巴细胞增殖的上调作用[J]. 生理学报 1999; 51 (4): .

Bai Haibo, Du Jizeng, Zheng Xiaoxiang. The enhancing effects of arginine-vasopressin on antibody level and lymphocyte proliferation of rats. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).