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c-fos基因在内皮素-1促肺泡Ⅱ型细胞表面活性物质合成中的作用

罗自强, 孙秀泓, 秦晓群

湖南医科大学生理学教研室.湖南,长沙 410078

摘要

应用反义技术探讨c-fos基因在ET-1调控肺泡Ⅱ型细胞(ATⅡ)表面活性物质(PS)合成的胞内信号转导中的作用。结果证实:ET-1可促进ATⅡ的PS合成,激活PKC上调c-fos基因表达是ET-1促ATⅡ细胞合成PS的胞内信号转导途径。

关键词： 内皮素-1; 肺泡Ⅱ型上皮细胞; 肺表面活性物质; 蛋白激酶C; c-fos基因

Role of c-fos gene in the pulmonary surfactant synthesis of cultured alveolar type Ⅱ cells induced by endothelin-1

Luo Ziqiang, Sun Xiuhong, Qin Xiaoqun

Department of Physiology,Hunan Medical University.Changsha 410078,Hunan

Abstract

The effects of endothelin-1 (ET-1) on pulmonary surfactant (PS) synthesis of cultured alveolar type Ⅱ cells (ATⅡ) were observed. The role of c-fos gene in cellular signal transduction of ET-1 was studied by antisense technology. The results demonstrated that ET-1 can enhance PS synthesis of ATⅡ cells and ET-1 stimulating the expression of c-fos gene mediated by PKC is a major signal transduction pathway of modulating PS synthesis.

Key words: Endothelin-1;Alveolar type Ⅱcells;Pulmonary surfactant;Protein kinase C;c-fos gene

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引用本文：

罗自强, 孙秀泓, 秦晓群. c-fos基因在内皮素-1促肺泡Ⅱ型细胞表面活性物质合成中的作用[J]. 生理学报 1999; 51 (3): .

Luo Ziqiang, Sun Xiuhong, Qin Xiaoqun. Role of c-fos gene in the pulmonary surfactant synthesis of cultured alveolar type Ⅱ cells induced by endothelin-1. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).