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中枢应用#beta#-内啡肽对大鼠血浆唾液酸水平的影响以及与免疫功能的关系

陈文芳, 陈蕾, 吕秀文, 陈家津

青岛大学医学院生理教研室.山东,青岛 266021；青岛大学医学院附属医院检验科.山东,青岛 266021

摘要

侧脑室注射#beta#-EP可明显降低大鼠血浆SA水平;血浆SA水平在ARC区注射#beta#-EP后明显降低,此效应可被M胆碱受体阻断剂阿托品或切断双侧颈迷走神经所阻断;ARC区注射#beta#-EP后,外周血CD3、CD4明显升高,CD8明显降低,CD4/CD8比值升高。

关键词： 血浆; 唾液酸; β-内啡肽; 侧脑室; 弓状核区; 淋巴细胞; 大鼠

Effect of #beta#-endorphin on plasma sialic acid level in rats and the relationship with the immune function

Chen Wenfang, Chen Lei, Lu Xiuwen, Chen Jiajin

Department of Physiology,The Medical College of Qingdao University.Qingdao 266021,Shandong

Abstract

The plasma SA level was significantly decreased after microinjection of #beta#-EP into the lateral ventricle (LV); When #beta#-EP was microinjection into nucleus arcuatus (ARC), the plasma SA level was significantly decreased (P<0.05). This effect can be blocked by i.v. atropine or vagotomy; Microinjection of #beta#-EP into ARC can cause the increase of CD3, CD4 and CD4/CD8, while CD8 was decreased.

Key words: Plasma;Sialic acid;#beta#-endorphin;Lateral ventricle;Nucleus arcuatus;Lymphocyte rat;

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引用本文：

陈文芳, 陈蕾, 吕秀文, 陈家津. 中枢应用#beta#-内啡肽对大鼠血浆唾液酸水平的影响以及与免疫功能的关系[J]. 生理学报 1999; 51 (3): .

Chen Wenfang, Chen Lei, Lu Xiuwen, Chen Jiajin. Effect of #beta#-endorphin on plasma sialic acid level in rats and the relationship with the immune function. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).