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大鼠侧脑室注射神经降压素对血压的作用

张小慧, 殷国湘, 倪慧

南京医科大学生理学教研室.江苏,南京 210029

摘要

脑中NT升高可使血压升高或降低;在NT引起升压反应的中枢环节中,有肾上腺素能#alpha#_(1)受体活动的参与;在NT引起降压反应的中枢环节中,有胆碱能M受体活动的参与。

关键词： 神经降压素; 血压; 哌唑嗪; 硫酸阿托品; 侧脑室注射

Effect of intracerebroventricular neurotensin injection on blood pressure in rat

Zhang Xiaohui, Yin Guoxiang, Ni Hui

Department of Physiology,Nanjing Medical University.Nanjing 210029,Jiangsu

Abstract

Injection of neurotensin (NT) (10 and 20#mu#g/rat) into the lateral cerebroventricle (icv) could induce a rise or a drop of blood pressure and a slowing down of heart rate in urethane anaesthetized male rats (1.2g/kg). The central pressor and depressor response to NT could be respectively blocked by pretreatment with #alpha#_(1)-receptor blocker praxosin (1.5#mu#g/3#mu#l, icv) and M receptor blocker atropine (2.5#mu#g/3#mu#l, icv). No significant changes in central cardiovascular responses to NT were observed following pretreatment with either H_(1) receptor blocker chlorpheniramin (50#mu#g/3#mu#l, icv) or H_(2) receptor blocker cimetidine (250#mu#g/2#mu#l, icv).

Key words: Neurotensin;Blood pressure;Prazosin;Atropine;Intracerebroventricular injection

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引用本文：

张小慧, 殷国湘, 倪慧. 大鼠侧脑室注射神经降压素对血压的作用[J]. 生理学报 1999; 51 (2): .

Zhang Xiaohui, Yin Guoxiang, Ni Hui. Effect of intracerebroventricular neurotensin injection on blood pressure in rat. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).