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中脑导水管周围灰质内注射抗阿片肽血清对神经降压素增强电针镇痛的影响

白波, 王宏, 刘文彦, 宋朝佑

济宁医学院神经生理研究室.山东,济宁 272113；第二军医大学神经生物学教研室.上海 200433

摘要

以钾离子透入引起大鼠甩尾反应作为痛反应指标,观察纳洛酮(NX)和抗阿片肽血清对大鼠中脑导水管周围灰质(PAG)内微量注射神经降压素(NT)增强电针镇痛作用的影响。结果提示:PAG内NT在针刺镇痛过程中发挥重要作用,NT增强电针镇痛的作用与甲-脑啡肽和#beta#-内啡肽有较密切的关系。

关键词： 神经降压素; 中脑导水管周围灰质; 电针镇痛; 抗甲-脑啡肽血清; 抗β-内啡肽血清; 抗强啡肽A_(1-13); 血清

Effect of anti-opioid peptide sera on the enhancement of electroacupuncture analgesia induced by neurotensin in PAG of rats

Bai Bo, Wang Hong, Liu Wenyan, Song Chaoyou

Laboratory of Neurophysiology,Jining Medical College.Jining 272113,Shandong；China

Abstract

With the use of potassium iontophoresis induced tail-flick for measuring the pain threshold, the effects of injecting neurotensin (NT), naloxone (NX), anti-metenkephalin serum (AMEKS), anti-#beta#-endorphin serum (AEPS) and anti-dynorphin A_(1-13) serum (ADYNS) into periaqueductal grey (PAG) on electroacupuncture (EA) analgesia in rats were investigated.

Key words: Neurotensin;Periaquedutal gray;Electroacupuncture analgesia; Antimetenkephalin serum;Antiendorphin serum;Antidynorphin A_(1-13) serum;

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引用本文：

白波, 王宏, 刘文彦, 宋朝佑. 中脑导水管周围灰质内注射抗阿片肽血清对神经降压素增强电针镇痛的影响[J]. 生理学报 1999; 51 (2): .

Bai Bo, Wang Hong, Liu Wenyan, Song Chaoyou. Effect of anti-opioid peptide sera on the enhancement of electroacupuncture analgesia induced by neurotensin in PAG of rats. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).