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小鼠脑内NO/NOS-cGMP信号系统与吗啡依赖形成的机制

方芳, 曹清, 宋福津, 王艳红, 刘景生

医科院中国协和医科大学基础医学研究所药理室.北京 100005；北京协和医院病理科.北京 100005

摘要

观察了吗啡依赖小鼠脑组织cGMP含量、钙依赖性及非钙依赖性NOS活性的变化、蛋白激酶A(protein kinase A,PKA)对NOS活性的磷酸化调节以及一氧化氮合酶(NOS)抑制剂对吗啡依赖形成的影响。

关键词： 吗啡; 依赖 一氧化氮合酶(NOS); cGMP; 磷酸化

Evidence for involvement of NO/NOS-cGMP signal system in morphine dependence

Fang Fang, Cao Qing, Song Fujin, Wang Yanhong, Liu Jingsheng

Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing 100005

Abstract

The present study was undertaken to observe changes in cGMP contents, calcium-dependent and non-calcium-dependent NOS activities in brain regions isolated from morphine-dependent mice as well as the effect of NOS inhibitor (L-NMMA) on the development of this dependence.

Key words: Morphine;Dependence;cGMP;Nitric oxide synthase

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引用本文：

方芳, 曹清, 宋福津, 王艳红, 刘景生. 小鼠脑内NO/NOS-cGMP信号系统与吗啡依赖形成的机制[J]. 生理学报 1999; 51 (2): .

Fang Fang, Cao Qing, Song Fujin, Wang Yanhong, Liu Jingsheng. Evidence for involvement of NO/NOS-cGMP signal system in morphine dependence. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).