过刊浏览

脂多糖对离体培养大鼠血管平滑肌细胞增殖的影响

李剑, 林树新, 李莹, 赵贺玲, 贾斌

第四军医大学基础部病理生理学教研室.陕西,西安 710032

摘要

低浓度脂多糖(LPS)促进血管平滑肌细胞(VSMC)增殖和DNA合成,而高浓度LPS却明显抑制VSMC增殖和DNA合成,降低其活力。这种抑制作用可能与LPS诱导VSMC产生的NO有关。

关键词： 脂多糖(LPS); 血管平滑肌细胞(VSMC); 增殖 一氧化氮(NO); 诱导性一氧化氮合酶(iNOS)

Effect of lipopolysaccharide on the proliferation of rat VSMCs in vitro

Li Jian, Lin Shuxin, Li Ying, Zhao Heling, Jia Bin

Department of Pathophysiology,The Fourth Military Medical University.Xi^an 710032,Shaanxi

Abstract

LPS of low dose stimulated the proliferation and the DNA synthesis of VSMCs, while LPS of high dose markedly inhibited them probably due to the increased NO production.

Key words: lipopolysaccharide(LPS);Vascular smooth muscle cells;Proliferation;Nitric oxide(NO)

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

李剑, 林树新, 李莹, 赵贺玲, 贾斌. 脂多糖对离体培养大鼠血管平滑肌细胞增殖的影响[J]. 生理学报 1999; 51 (1): 14-18.

Li Jian, Lin Shuxin, Li Ying, Zhao Heling, Jia Bin. Effect of lipopolysaccharide on the proliferation of rat VSMCs in vitro. Acta Physiol Sin 1999; 51 (1): 14-18 (in Chinese with English abstract).