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谷氨酸对大鼠海马CA_(1)区神经元的短暂性外向K~(+)电流的影响

许长庆, 张宗明, 夏作理, 吴才宏, 周培爱

广东省江门市中心医院神经内科.广东,江门 529071；北京医科大学附属第三医院外科.北京 100083；泰山医学院附属医院老年病科.山东,泰安 271000；北京大学生物膜与膜生物工程国家开放实验室.北京 100871

摘要

谷氨酸对短暂性K~(+)电流有明显抑制作用,且呈明显浓度依赖性、时间依赖性和部分电压依赖性。结果表明,谷氨酸对K~(+)通道的影响在中枢神经系统中具有重要作用。

关键词： 谷氨酸; 海马; 神经元; 电生理学

Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in CA_(1) sector in rats

Xu Changqing, Zhang Zongming, Xia Zuoli, Wu Caihong, Zhou Peiai

Department of Neurology,Central Hospital of Jiangmen District.Jiangmen 529071,Guangdong；China；Department of Gerontology,Affiliated Hospital,Taishan Medical College.Tai^an 271000,Shandong

Abstract

The effects of glutamate on the transient outward potassium current of dissociated hippocampal CA_(1) neurons of 7-10d rats were studied by the whole-cell patch clamp technique. It was found that glutamate could block the transient potassium current in a dose- and time-dependent manner. The effect was partly voltage-dependent. These results suggest that glutamate may decrease the membrane conductance of K~(+) channels in hippocampal neurons.

Key words: Glutamate;Hippocampus;Neurons;Electrophysiology

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引用本文：

许长庆, 张宗明, 夏作理, 吴才宏, 周培爱. 谷氨酸对大鼠海马CA_(1)区神经元的短暂性外向K~(+)电流的影响[J]. 生理学报 1999; 51 (1): 55-59.

Xu Changqing, Zhang Zongming, Xia Zuoli, Wu Caihong, Zhou Peiai. Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in CA_(1) sector in rats. Acta Physiol Sin 1999; 51 (1): 55-59 (in Chinese with English abstract).