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TRPM2：氧化应激敏感的多功能离子通道

茹筱晨^*, 姚晓强

香港中文大学深圳研究院、生物医学学院，香港

摘要

瞬时受体电位(transient receptor potential, TRP)超家族是一组非选择性阳离子通道，分为7个亚家族。TRPM亚家族包括8个不同的成员，TRPM1~8。TRPM2广泛表达于可兴奋细胞和非兴奋性细胞，形成Ca2+通透性阳离子通道，并发挥不同的细胞功能。TRPM2通道可被ADP-核糖(ADPR)、Ca2+、H2O2以及其他活性氧(ROS)所激活。现已证明，TRPM2作为氧化应激传感器，介导了氧化应激引起的细胞内Ca2+浓度升高，并参与多种细胞的生理/病理过程。丰富的证据表明，TRPM2可作为氧化应激相关疾病的一个潜在的治疗靶点。本文对以上方面的研究进展做一综述。

关键词： TRPM2; 氧化应激; Ca2+信号; 心血管疾病; 炎症

分类号：Q71

TRPM2: a multifunctional ion channel for oxidative stress sensing

Xiaochen Ru^*, Xiaoqiang Yao

Shenzhen Research Institute and School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China

Abstract

Transient receptor potential (TRP) superfamily is a superfamily of cation channels that can be divided into seven subfamilies. TRPM2 is the second member of the TRPM subfamily, which includes eight members, namely TRPM1–8. TRPM2 is widely expressed in excitable and non-excitable cells, where it forms a Ca2+-permeable cation channel and performs diverse cellular functions. TRPM2 channels are activated by ADP-ribose (ADPR), Ca2+, H2O2 and other reactive oxygen species (ROS). It is established that TRPM2 serves as a cellular sensor for oxidative stress, mediating oxidative stress-induced [Ca2+]i increase and contributing to pathological processes in many cell types. Accumulating evidence has indicated that TRPM2 is a potential therapeutic target for oxidative stress-related diseases. This review will highlight recent progress in this field.

Key words: TRPM2; oxidative stress; Ca2+ signaling; cardiovascular diseases; inflammation

收稿日期：　　录用日期：

通讯作者：茹筱晨　　E-mail: ruxiaochen2013@gmail.com

引用本文：

茹筱晨, 姚晓强. TRPM2：氧化应激敏感的多功能离子通道[J]. 生理学报 2014; 66 (1): 7-15.

Xiaochen Ru, Xiaoqiang Yao. TRPM2: a multifunctional ion channel for oxidative stress sensing. Acta Physiol Sin 2014; 66 (1): 7-15 (in Chinese with English abstract).