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糖皮质激素快速抑制高钾离子诱导嗜铬细胞瘤细胞内游离钙浓度升高的作用及其特征

娄淑杰, 王晨光, 黄秀英, 陈宜张

第二军医大学生理学教研室.上海 200433；中科院发育生物学研究所开放实验室.北京 100081

摘要

应用钙离子特异荧光指示剂Fura-2/AM,使用Miracal影像系统(Miracal Image System)检测了糖皮质激素对高钾离子升高嗜铬细胞瘤细胞(PC12细胞)内游离钙浓度([Ca~(2+)]_(i))作用的影响。

关键词： 糖皮质激素; PC12细胞; 细胞内游离钙离子浓度; 高钾离子; Fura-2／AM

Effect of glucocorticoid on [Ca~(2+)]_(i) induced by high-K~(+) in single PC12 cells and its characteristics

Lou Shujie, Wang Chenguang, Huang Xiuying, Chen Yizhang

Institute of Neuronscience,Department of Physiology,The Second Military Medical University.Shanghai 200433；China

Abstract

The effect of glucocorticoid on the increase of cytosolic free calcium ([Ca~(2+)]_(i)) induced by high-K~(+) was investigated in pheochomocytoma PC12 cells.

Key words: Glucocorticoid;PC12 cells;[Ca~(2+)];High-K~(+);Fura-2/AM

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引用本文：

娄淑杰, 王晨光, 黄秀英, 陈宜张. 糖皮质激素快速抑制高钾离子诱导嗜铬细胞瘤细胞内游离钙浓度升高的作用及其特征[J]. 生理学报 1998; 50 (5): .

Lou Shujie, Wang Chenguang, Huang Xiuying, Chen Yizhang. Effect of glucocorticoid on [Ca~(2+)]_(i) induced by high-K~(+) in single PC12 cells and its characteristics. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).