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孤儿受体TR3在小鼠睾丸中的定位和表达

摘要

在小鼠睾丸中有显著量的孤儿受体TR3 mRNA和蛋白表达,其表达量在不同曲细精管有明显的差异;孤儿受体TR3蛋白主要定位于生精细胞,其mRNA在生精细胞特异表达,主要在精原细胞和发育早期的初级精母细胞表达,提示孤儿受体TR3在小鼠曲细精管精子发生的早期阶段中起着调控作用。

关键词： 孤儿受体TR3; 原位杂交; 免疫组织化学; 精子发生

Localization and expression of TR3 orphan receptor in mouse testis

Abstract

The results showed that both TR3 and its mRNA were expressed in a significant amount in mouse testis, and the expression level of TR3 mRNA was different in different seminiferous tubules. TR3 mRNA was specifically expressed in germ cells, mainly in spermatogonia and less advanced primary spermatocytes, whereas TR3 receptor protein was mainly localized in germ cells. It is suggested that TR3 may play an important role in regulating the early stage of germ cell development in mice.

Key words: Orphan receptor TR3;In situ hybridization immunohistochemistry;Spermatogenesic ;

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引用本文：

. 孤儿受体TR3在小鼠睾丸中的定位和表达[J]. 生理学报 1998; 50 (4): .

. Localization and expression of TR3 orphan receptor in mouse testis. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).