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八肽胆囊收缩素对吗啡抑制大鼠离体空肠电与收缩活动的对抗作用

摘要

吗啡能抑制ACh对空肠峰波发放和收缩的加强作用;CCK-8可对抗吗啡的作用;在此基础上,CCK-A受体拮抗剂devazepide(10nmol/L)能完全翻转CCK-8的抗吗啡作用,但是CCK-B受体拮抗剂L-365,260在10nmol/L时可部分翻转、在30nmol/L时能完全翻转CCK-8的作用。

关键词： 八肽胆囊收缩素; CCK受体; 拮抗剂; 空肠; 电活动; 收缩

Antagonistic effect of CCK-8 on morphine-inhibited electrical and contractile activities of rat jejunum in vitro

Abstract

The results showed that the potentiation of acetylcholine (ACh) on both the burst of spike and the contractility were inhibited by morphine, which could be completely antagonized by CCK-8. The CCK-8 effect, again, could be suppressed by CCK-A receptor antagonist devazepide (10mol/L), but partially by CCK-8 receptor antagonist L-365, 260 at 10nmol/L or completely at concentration of 30nmol.L.

Key words: Cholecystokinin octapeptide;Cholecystokinin receptor;Antagonist jejunum; Electrical activity;Contraction;

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引用本文：

. 八肽胆囊收缩素对吗啡抑制大鼠离体空肠电与收缩活动的对抗作用[J]. 生理学报 1998; 50 (4): .

. Antagonistic effect of CCK-8 on morphine-inhibited electrical and contractile activities of rat jejunum in vitro. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).