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牛磺酸对急性低氧促培养的兔肺小动脉平滑肌细胞产生血栓素A_(2)和前列环素的影响

摘要

观察了牛磺酸对分离培养家兔肺小动脉平滑肌细胞(PASMCs)在急性低氧条件下培养液中血栓素B_(2)(TxB_(2))和6-酮-前列腺素F_(1#alpha#)(6-keto-PGF_(1#alpha#))含量及其比值变化的影响,结果表明,牛磺酸可能通过抑制PASMCs内的TxA_(2)合成酶的活性和增强前列环素(PGI_(2))合成酶的活性拮抗低氧增强PASMCs产生TxA_(2)和PGI_(2),使TxA_(2)与PGI_(2)的比值显著降低而逆转氧性肺血管收缩。

关键词： 血栓素A_(2); 前列环素; 牛磺酸; 肺小动脉平滑肌细胞; 吲哚美辛; 低氧

Effects of taurine enhancement of synthesis of TxA_(2) and PGI_(2) in cultured intra-pulmonary arteriolar smooth muscle cells under acute hypoxia

Abstract

The results of the present study demonstrated that the concentrations of thromboxane B_(2) (TxB_(2)a) and 6-keto-prostaglandin F_(1#alpha#) (6-keto-PGF_(1#alpha#)), and their ratio were significantly increased in the medium of intra-pulmonary arteriolar smooth muscle cells (PASMCs) under acute hypoxia. Under either normoxia or hypoxia the concentration of TxB_(2) was significantly decreased with addition of taurine, while that of 6-keto-PGF_(1#alpha#) was significantly increased. With the addition of indomethacin, however, under similar conditions, the concentrations of both TxB_(2) and 6-keto-PGF_(1#alpha#) were decreased. Furthermore, the effect of indomathecin on TxA_(2) and 6-keto-PGF_(1#alpha#) concentrations could be reversed by taurine.

Key words: Thromboxane A_(2);Prostacyclins;Taurine;Pulmonary arteriolar smooth muscle cells;Indomethacin;Hypoxia

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引用本文：

. 牛磺酸对急性低氧促培养的兔肺小动脉平滑肌细胞产生血栓素A_(2)和前列环素的影响[J]. 生理学报 1998; 50 (4): .

. Effects of taurine enhancement of synthesis of TxA_(2) and PGI_(2) in cultured intra-pulmonary arteriolar smooth muscle cells under acute hypoxia. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).