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电生理学特性得到确定的大鼠脊髓背根神经节细胞内谷氨酸和P物质的共存

摘要

在离体灌流带脊髓和坐骨神经的标本上,对脊髓背根神经节(DRG)细胞的电生理学特性、对P物质(SP)受体激动剂的反应及谷氨酸(Glu)/SP共存的特点进行了研究。结果提示DRG中A_(#alpha#/#beta#)细胞与C细胞的化学解剖和电生理特性不同,SP可能通过作用于节细胞上的自身受体易化冲动的发放。

关键词： 背根神经节; 细胞内记录; 细胞内标记; 递质共存; 免疫荧光多重染色; 大鼠

Co-existence of glutamate and substance P in electrophysiologically identified dorsal root ganglion neurons of rats

Abstract

Electrophysiological properties, reaction to sustance P (SP) receptor agonist, and co-existence of glutamate (Glu) and SP in neurons of the spinal dorsal root ganglion (DRG) of the rat were investigated in vitro. The present results indicated that there were some differences in chemicoanatomical and electrophysiological properties between A_(#alpha#/#beta#) type and C type neurons, and SP might facilitate the discharge of DRG neurons through activating SP autoreceptors on their membrane.

Key words: Dorsal root ganglion;Neurotransmitter co-existence;Intracellular recording; Intracellular labeling;Immunofluorescent histochemical multi-staining;Rat

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引用本文：

. 电生理学特性得到确定的大鼠脊髓背根神经节细胞内谷氨酸和P物质的共存[J]. 生理学报 1998; 50 (4): .

. Co-existence of glutamate and substance P in electrophysiologically identified dorsal root ganglion neurons of rats. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).