过刊浏览

ACTH_(4-9)类似物对小鼠海马突触体Ca~(2+)水平的调节作用

摘要

较低剂量的Org2766对突触体内[Ca~(2+)]_(i)的影响不明显,却显著降低突触体对~(45)Ca~(2+)的摄取;高剂量的Org2766增加突触体内[Ca~(2+)]_(i),但对突触体的~(45)Ca~(2+)摄取无影响。较低剂量的Org2766可拮抗茴香霉素(ANI)升高突触体内[Ca~(2+)]_(i)和~(45)Ca~(2+)摄取量的作用,高剂量的Org2766无此效应。

关键词： Org2766; 海马突触体; Fura-2; Ca~(2＋)_(i); ~(45)Ca~(2＋)摄取

Regulation of ACTH_(4-9) analogue on the Ca~(2+) level of mouse hippocampal synaptosomes

Abstract

Low dose of Org2766 did not change synaptosomal [Ca~(2+)]_(i) level, but decreased ~(45)Ca~(2+) uptake. High dose of Org2766 increased [Ca~(2+)]_(i) without affecting ~(45)Ca~(2+) uptake. Low dose of Org2766 inhibited the anisomysin-induced increase of synaptosomal [Ca~(2+)]_(i) while high dose had no effect.

Key words: ACTH_(4-9)analogUe Org2766;Hippocampal synaptosomes;Fure-2;[ Ca~(2+)]_(i); ~(45)Ca~(2+)uptake

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

. ACTH_(4-9)类似物对小鼠海马突触体Ca~(2+)水平的调节作用[J]. 生理学报 1998; 50 (4): .

. Regulation of ACTH_(4-9) analogue on the Ca~(2+) level of mouse hippocampal synaptosomes. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).