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枸杞多糖对肾性高血压大鼠离体血管反应性的影响及其机制

摘要

利用两肾一夹(2K1C)肾性高血压(RH)大鼠模型,观察枸杞多糖(LBP)对高血压大鼠血压的影响以及离体主动脉环内皮细胞在调节血管张力中的功能改变,探讨LBP对高血压发生发展的影响及其机制。结果表明,LBP降低2K1C大鼠增强的血管收缩反应,增加内皮依赖性的舒张。

关键词： 枸杞多糖; 高血压; 内皮; 内皮舒张因子

The effect of lycium barbarum polysaccharide on vascular tension in two-kidney, one clip model of hypertension

Abstract

In the present study, the effects of lycium barbarum polysaccharide (LBP) on endothelial function in the two-kidney, one clip model of hypertension were abserved. These results suggested that the role of LBP in decreasing vasoconstrition to PE may be mediated by increase of the effects or/and production of endothelium-derived relaxation factor (EDRF). LBP increased formation of EDRF may be related to increase the substrate of EDRF.

Key words: Lycium barbarum polysaccharide;Hypertension;Endothelium-derived relaxing factor;

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引用本文：

. 枸杞多糖对肾性高血压大鼠离体血管反应性的影响及其机制[J]. 生理学报 1998; 50 (3): .

. The effect of lycium barbarum polysaccharide on vascular tension in two-kidney, one clip model of hypertension. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).