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#gamma#-氨基丁酸诱发人精子顶体反应及其受精能力

摘要

GABA可诱发人获能精子发生AR,且随精子获能进程而显著增加,并存在明显的量效关系,该作用可被P_(4)加强。GABA还可明显地激发胞内钙[Ca~(2+)]_(i)升高。GABA诱发精子AR不仅可被Ca~(2+)螯合剂EGTA所拮抗,而且为Ca~(2+)通道阻滞剂La~(3+)所阻断。此外,GABA还可明显地促进人精子的穿卵能力。

关键词： GABA; 孕酮; 精子; 顶体反应; 精子穿卵试验; 胞内钙测定

GABA initiates the acrosome reaction and fertilizing ability in human sperm

Abstract

Results indicate that GABA may be involved in the modulation of the AR and the fertilization process in capacitated human spermatozoa through a calcium mediated mechanism, thus opening up posibilities for studies of signal transductions through activation of the GABA_(A) receptor present on the sperm surface.

Key words: GABA;Progesterone;Sperm;Acrosome reaction;Sperm penetration assay (SPA) [Ca~(2+)]_(i) assay;

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引用本文：

. #gamma#-氨基丁酸诱发人精子顶体反应及其受精能力[J]. 生理学报 1998; 50 (3): .

. GABA initiates the acrosome reaction and fertilizing ability in human sperm. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).