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内皮素-1对肺表达活性物质分泌的调控

摘要

采用离体大鼠非灌流肺,观察生理浓度内皮素-1(ET-1)对肺表面活性物质(PS)分泌的影响。结果提示,生理水平的ET-1通过PKC的介导参与肺PS分泌的调控;ET-1可诱导肺组织产生ET。

关键词： 内皮素-1; 肺表面活性物质; 蛋白激酶C; 离体非灌流肺

Modulation of endothelin-1 on pulmonary surfactant secretion

Abstract

The effects of endothelin-1 (ET-1) at physiological level on the secretion of pulmonary surfactant (PS) were studied on isolated nonperfused rat lungs. Results suggest that ET-1 at the physiological concentration is involved in modulating PS secretion through a PKC-dependent pathway, and can also promote ET production in lungs.

Key words: Endothelin-1;Pulmonary surfactant;Protein kinase C;Isolated nonperfused lung

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引用本文：

. 内皮素-1对肺表达活性物质分泌的调控[J]. 生理学报 1998; 50 (3): .

. Modulation of endothelin-1 on pulmonary surfactant secretion. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).