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实验性癫痫时海马内一氧化氮合酶的变化及其与谷氨酸受体的关系

摘要

应用免疫组织化学方法观察了青霉素致痫时海马内神经元型一氧化氮合酶表达的时程变化及海马内微量注射NMDA受体拮抗剂MK-801和非NMDA受体拮抗剂DNQX对大鼠海马内nNOS表达的影响。癫痫时一氧化氮的增加受到NMDA和非NMDA受体的调节;MK-801和DNQX对神经元的保护作用可能与其对一氧化氮合酶的影响有关。

关键词： 癫痫; 海马; 神经元型一氧化氮合酶; DNQX; MK-801

The relation between changes of nitric oxide synthase in hippocampus and activities of excitatory amino acid receptor during epilepsy

Abstract

The time course of alteration in neuronal nitric oxide synthase (nNOS) and the influence of glutamate receptor antagonists on immunoreactivity of nNOS were investigated immunohistochemically in rat hippocampus during penicillin-induced epilepsy. These results suggest that the increase of nitric oxide may be related to the injury of neurons during and aft er epilepsy; the changes of nNOS may be related to the activity of NMDA and non-NMDA receptors. Neuron protective effect of MK-801 and DNQX may be in part mediated by nNOS.

Key words: Epilepsy;Hippcampus;Neural nitric oxide synthase;DNQX;MK-801

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引用本文：

. 实验性癫痫时海马内一氧化氮合酶的变化及其与谷氨酸受体的关系[J]. 生理学报 1998; 50 (4): .

. The relation between changes of nitric oxide synthase in hippocampus and activities of excitatory amino acid receptor during epilepsy. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).