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SKF38393抑制大鼠DRG分离神经元GABA-激活电流

摘要

在大鼠新鲜分离DRG神经元标本上应用全细胞膜片箝记录,观察了多巴铵D_(1)受体的选择性激动剂(±)SKF38393HCI对GABA-激活电流的作用。结果表明:细胞内加蛋白激酶抑制剂H-7后,SKF38393对GABA的抑制作用完全消除,看来SKF38393对GABA-激活电流的抑制作用可能是由于SKF38393使GABA受体通道复合体胞内磷酸化所致。

关键词： 背根神经节; 全细胞膜片箝记录; 多巴胺D_(1)-受体激动剂SKF38393; γ-氨基丁酸; 抑制作用

Inhibition by SKF38393 of GABA-activated currents in rat DRG neurons

Abstract

Experiments were performed on neurons freshly isolated from rat DRG using whole-cell patch-clamp techniques. Results suggesting that the inhibition by SKF38393 of the GABA-activated current might be a result of intracellular phosphorylation of GABA_(A) receptor.

Key words: Dorsal root ganalion;Whole-cell patch-clamp recoiling;Dopahane D_(1) receptor agonist SKF3839;GABA;Inhibition

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引用本文：

. SKF38393抑制大鼠DRG分离神经元GABA-激活电流[J]. 生理学报 1998; 50 (3): .

. Inhibition by SKF38393 of GABA-activated currents in rat DRG neurons. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).