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外周P物质受体介导伤害性刺激所致脊髓背角c-fos基因的表达

摘要

用免疫组化染色方法,观察了P物质受体在外周对伤害性刺激信息的介导作用。结果提示,SP在外周具有致痛作用,该作用至少部分是通过SP与SP受体结合而参与介导伤害性信息向脊髓传递。

关键词： P物质; P物质受体; c－fos; 脊髓背角; 伤害性刺激; 大鼠

Peripheral substance P receptor mediating c-fos gene expression in the spinal dorsal horn induced by peripheral noxious stimulation

Abstract

Employing immunohistochemical staining for FOS protein, which is the expression product of c-fos proto-oncogene, the role of substance P receptor (SPR) in noxious information transmission at peripheral terminals of the dorsal root ganglion cells was investigated by means of a selective SPR antagonist L668, 169 and agonist Sar-SP. These results indicated the SP might contribute to the transmission of nociceptive information and induce noxious sensation, at least in part by activating SPR in peripheral terminals of the dorsal root ganglion cells.

Key words: Substance P;Substance P receptor;c-fos;Dosal horn of the spinal cord;Noxious stimulation;Rat

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引用本文：

. 外周P物质受体介导伤害性刺激所致脊髓背角c-fos基因的表达[J]. 生理学报 1998; 50 (3): .

. Peripheral substance P receptor mediating c-fos gene expression in the spinal dorsal horn induced by peripheral noxious stimulation. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).