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cGMP对原代培养猪冠状动脉平滑肌细胞钙激活钾通道的作用

摘要

在cell-attached膜片方式下,当浴液内游离Ca~(2+)浓度为10~(-7)mol/L,膜电位为+70mV时,不同浓度的cGMP的膜透过类似物8-bromo-cGMP(0.25mmol/L,0.50mmol/L,1.00mmol/L)。对此类通道有明显的激活作用;在inside-out膜片方式下,1.00mmol/L的8-bromo-cGMP对通道却无激活作用。

关键词： 3′ 5′－环一磷酸鸟苷; 血管平滑肌; 膜片箝技术; 钙激活钾通道

Effect of cGMP on calcium-activated potassium channels in primary cultured porcine coronary artery smooth muscle cells

Abstract

Key words: Guanosine 3′ 5′-cyclic monophosphate;Vascular smooth muscle cells;Patch clamp technique;Calcium-activated potassium channels

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引用本文：

. cGMP对原代培养猪冠状动脉平滑肌细胞钙激活钾通道的作用[J]. 生理学报 1998; 50 (1): .

. Effect of cGMP on calcium-activated potassium channels in primary cultured porcine coronary artery smooth muscle cells. Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).