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中央杏仁核、外侧下丘脑/穹窿周围区、室旁核均参与岛皮层升压反应

顾蕴辉, 徐伟科, 吕贻春, 王益光, 谭璐

北京医科大学生理系.北京 100083

摘要

实验用乌拉坦麻醉、箭毒制动、人工呼吸的大鼠。将谷氨酸注入岛皮层(INS)以及将P物质(SP)注入外侧下丘脑/穹窿周围区(LH/PF)或室旁核均引起升压反应。INS-升压反应可被中央杏仁核(AC)内预先注射普鲁卡因或谷氨酸二乙酯(GDEE,谷氨酸拮抗剂)以及LH/PF内注射[D-Pro~(2),D-Phe~(7),D-Trp~(9)]-SP(DPDPDT, SP拮抗剂)明显衰减,但LH/PF内GDEE预处理对该反应无明显影响。室旁核内预先注射普鲁卡因或DPDPDT也使INS-升压反应显著减小。

关键词： 岛皮层; 中央杏仁核; 外侧下丘脑; 室旁核; P物质拮抗剂

Involvement of nucleus amygdaloideus centralis, lateral hypothalamus/perifornical region and nucleus paraventricularis in insular cortex-pressor response

Gu Yunhui, Xu Weike, Lu Yichun, Wang Yiguang, Tan Lu

Department of Physiology, Beijing Medical University. Beijing 100083

Abstract

In urethane-anesthetized, tubocurarine- immobilized and artificially ventilated rats, glutamate (Glu) injection into the insular cortex (INS) and substance P injection into the lateral hypothalamus-perifornical region (LH/PF) or nucleus paraventricularis (NPV) caused pressor responses. Preinjection of procaine or glutamate diethyl ester (GDEE, a glutamate antagonist) bilaterally into the nucleus amygdaloideus centralis (AC) and [D-Pro~(2), D-Phe~(7), D-Trp~(9)] -substance P (DPDPDT, a substance P antagonist), but not GDEE, into the LH/PF markedly attenuated the pressor response induced by glutamate injection into the INS. Procaine or DPDPDT preinjection into the NPV also reduced the INS-pressor response.

Key words: Insular cortex;Amygdaloideus centralis;Lateral hypothalamus;Nucleus paraventricularis;Substance P antagonist

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引用本文：

顾蕴辉, 徐伟科, 吕贻春, 王益光, 谭璐. 中央杏仁核、外侧下丘脑/穹窿周围区、室旁核均参与岛皮层升压反应[J]. 生理学报 1997; 49 (2): .

Gu Yunhui, Xu Weike, Lu Yichun, Wang Yiguang, Tan Lu. Involvement of nucleus amygdaloideus centralis, lateral hypothalamus/perifornical region and nucleus paraventricularis in insular cortex-pressor response. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).